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In this article, we take a look at nine types of pills and supplements that are proposed to help support weight loss, examining the evidence for each one. Unfortunately, NO supplement or pill really works that well for weight loss. They may give your metabolism a bit of a nudge and help you lose a few pounds, but that’s where it ends, unfortunately. Weight Loss Supplements for Women Over 40. If you’re overweight or obese, some of the best supplements for women over 40 help you achieve or maintain a healthy weight and even aid in fat loss! Examples include: #1 Protein Powder. Here are 7 of the most effective weight loss supplements for women. How well do they work? Natural weight loss supplements. 01-04-2019 This weight loss includes both body fat and water weight. One study in healthy women with obesity reported that a very low carb diet was more effective than a low fat diet for short-term weight loss .